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CELECOXIB – ORAL
COMMON BRAND NAME(S): Celebrex
WARNING: Nonsteroidal anti-inflammatory drugs (including celecoxib) may rarely increase the risk of a heart
attack or stroke. The risk may be greater if you have heart disease or increased risk for heart disease (for example,
due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes), or with longer
use. This drug should not be taken right before or after heart bypass surgery (CABG). Also, this drug may
infrequently cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without
warning symptoms at any time while taking this drug. Older adults may be at higher risk for this effect. (See also
Precautions and Drug Interactions sections.) Stop taking celecoxib and get medical help right away if you notice any
of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit
that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side
of the body, sudden vision changes, slurred speech. Talk with your doctor or pharmacist about the risks and benefits
USES: This medication is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which
relieves pain and swelling (inflammation). It is used to treat arthritis, acute pain, and menstrual pain and
discomfort. The pain and swelling relief provided by this medication help you perform more of your normal daily
activities. If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or
using other medications to treat your pain. See also Warning section. This drug works by blocking the enzyme in
your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for
the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in
this section only if it has been so prescribed by your health care professional. This medication may also be used to
treat gout attacks.
HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using celecoxib and each
time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as
directed by your doctor, usually once or twice daily. To decrease the chance of stomach upset, this drug is best taken
with food. The dosage is based on your medical condition and response to treatment. Take this medication at the
lowest effective dose and only for the prescribed length of time (see also Warning section). Take this medication with
a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Do not lie down for 10
minutes after taking this medication. For certain conditions (such as arthritis), it may take up to two weeks of taking
this drug regularly before you get the full benefit. If you are taking this drug on a \” as needed\” basis (not on a
regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you
wait until the pain has worsened, the medication may not work as well.
SIDE EFFECTS: See also Warning section. Stomach upset or gas may occur. If either of these effects persists or
worsens, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication
because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this
medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including
severe headache, unexplained weight gain, swelling of the hands or feet, pain/swelling/warmth in the groin/calf,
change in the amount of urine, difficult/painful swallowing, unusual tiredness. This drug may rarely cause serious
(possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including dark
urine, persistent nausea/vomiting/loss of appetite, severe stomach/abdominal pain, yellowing eyes/skin. A very
serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a
serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness,
trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above,
contact your doctor or pharmacist.
PRECAUTIONS: See also Warning section. Before taking celecoxib, tell your doctor or pharmacist if you are allergic to it; or to aspirin, other NSAIDs (such as ibuprofen), other COX-2 inhibitors; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), liver disease, stomach/intestine/esophagus problems (such as bleeding, ulcers, recurring heartburn), heart disease (such as angina, heart attack), high blood pressure, stroke, blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps). Kidney problems can sometimes occur with the use of NSAID medications, including celecoxib. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have any unusual change in the amount of urine. This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and smoking. Consult your doctor or pharmacist for more information. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially stomach bleeding and kidney problems. Caution is advised when using this drug for children with a certain type of arthritis (systemic-onset juvenile rheumatoid arthritis) because they may be at increased risk for a very serious bleeding/clotting problem (disseminated intravascular coagulation). Get medical help right away if your child develops sudden bleeding/bruising or bluish skin in the fingers/toes. Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery. This medication passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breastfeeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor\’s approval. Some products that may interact with this drug include aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, lithium, pemetrexed, \”water pills\” (diuretics such as furosemide). This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, \”blood thinners\” such as dabigatran/enoxaparin/warfarin, among others. Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as naproxen or ibuprofen). These drugs are similar to celecoxib and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.