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 Herceptin • 30 Recon solution, 150 mg

Herceptin (Trastuzumab) is used to treat certain breast or stomach cancers that produce more than the normal

amount of a certain substance called HER2 protein. Trastuzumab belongs to a class of medications known as

monoclonal antibodies. It works by slowing or stopping the growth of cancer cells. This monograph is about the

following trastuzumab products: trastuzumab, trastuzumab-anns.


This medication is given by slow injection into a vein by a health care professional, usually once every week or once

every 3 weeks. The first injection is given over at least 90 minutes. The dosage is based on your medical condition,

response to treatment, weight, and other medications you may be taking. Be sure to tell your doctor and pharmacist

about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Use this

medication regularly to get the most benefit from it. To help you remember, mark the days on the calendar when you

need to receive the medication. Your doctor may prescribe other medications (such as acetaminophen,

diphenhydramine) for you to take before each dose to help prevent serious side effects. Follow your doctor’s

directions carefully.


Redness/irritation at the injection site, diarrhea, muscle/joint/back pain, stomach/abdominal pain, headache,

trouble sleeping, nausea, vomiting, mouth sores, and loss of appetite may occur. Nausea and vomiting can be severe.

In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small

meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects

last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this

medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people

using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects,

including symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness,

unusual/sudden weight gain), bone pain, numbness/tingling, mental/mood changes, fast/pounding heartbeat, easy

bruising/bleeding. Get medical help right away if you have any very serious side effects, including the weakness on

one side of the body, slurred speech, vision changes, confusion. This medication may lower your ability to fight

infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have

worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn’t go away, fever,

chills, cough). Trastuzumab can commonly cause a rash that is usually not serious. However, you may not be able to

tell it apart from a rare rash that could be a sign of a severe reaction. Tell your doctor right away if you develop any

rash. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any

symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat),

severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not

listed above, contact your doctor or pharmacist.


Before using trastuzumab, tell your doctor or pharmacist if you are allergic to it; or to any trastuzumab, trastuzumab

emtansine, or trastuzumab-hyaluronidase products; or if you have any other allergies. This product may contain

inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/recent

infection, heart disease, lung problems, previous cancer treatments (including radiation treatment). Trastuzumab

can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have

infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed

to an infection or for more details. Do not have immunizations/vaccinations without the consent of your doctor.

Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose). To

lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and

avoid activities such as contact sports. This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you

dizzier. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit

alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your

doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal

products). Older adults may be at greater risk for heart problems (such as heart failure) while using this drug. Tell

your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using

trastuzumab. Trastuzumab may harm an unborn baby. Ask about reliable forms of birth control while using this

medication and for 7 months after stopping treatment. If you become pregnant, talk to your doctor right away about

the risks and benefits of this medication. It is unknown if this drug passes into breast milk. Consult your doctor

before breast-feeding while using this medication and for 7 months after stopping treatment.

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