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Nimetazepam (marketed under brand name Erimin and Laval) is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized by a team at Hoffmann-La Roche in 1962. It possesses hypnotic, anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam is also an anticonvulsant. It is sold in 5 mg tablets known as Erimin and Laval. It is generally prescribed for the short-term treatment of severe insomnia in patients who have difficulty falling asleep or maintaining sleep. The sole global manufacturer of Nimetazepam (Sumitomo Japan) has ceased manufacturing Erimin since early November 2015. Patients being prescribed Erimin are being switched to Laval and other hypnotics, e.g. estazolam, nitrazepam, flunitrazepam, etc.
Taken orally, Nimetazepam has very good bioavailability with nearly 100% being absorbed from the gut. It is among the most rapidly absorbed and quickest acting oral benzodiazepines, and hypnotic effects are typically felt within 15–30 minutes after oral ingestion. The blood level decline of the parent drug was biphasic with the short half-life ranging from 0.5–0.7 hours and the terminal half-life from 8 to 26.5 hours (mean 17.25 hours). It is the N-methylated analog of nitrazepam (Mogadon, Alodorm), to which it is partially metabolized. nitrazepam has a long elimination half-life, so the effects of repeated dosage tend to be cumulative.
Users should note that that as with benzodiazepines, the sudden discontinuation of thienodiazepines can be dangerous or even life-threatening for individuals who have been using the substance regularly for extended periods of time, as it can result in fatal seizures. As a result, individuals who find themselves physically dependent on this substance are highly advised to taper their dose by gradually lowering the amount taken each day over a prolonged period of time instead of stopping their intake abruptly.
Due to its high abuse and addiction potential and ability to cause alcohol-like blackout states, it is highly advised to use proper harm reduction practices if using this substance.